Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 25;20:4. doi: 10.1186/s12950-023-00328-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — β-FNAs effect on LPS-induced IL-6 expression in the whole brain and brain regions (hippocampus, prefrontal cortex, and cerebellum/brain stem) of male and female C57BL/6J mice. Mice (n = 5–6/group) were injected (i.p.) with saline (control), LPS (0.83 mg/kg), LPS followed immediately by β-FNA treatment (50 mg/kg; i.p.; LPS + β-FNA), or LPS followed by β-FNA 10 h post-LPS (LPS + β-FNA 10 h). 24 h post-LPS, mice were terminated followed by tissue collection. Levels of IL-6 in whole brain (A), hippocampus (B), prefrontal cortex (C), and cerebellum/brain stem (D) of tissue homogenates were measured by ELISA. Data are reported as mean ± SEM. Two-way ANOVA indicated no significant main effect of treatment (p = 0.70), sex (p = 0.84), or interaction (p = 0.89) on IL-6 levels in the whole brain. Two-way ANOVA determined IL-6 in the hippocampus showed significant main effects of treatment (p < 0.0001), but not sex (p = 0.25), or interaction (p = 0.89). In the prefrontal cortex two-way ANOVA determined IL-6 showed significant main effects of sex (p < 0.001), but not treatment (p = 0.56), or interaction (p = 0.083). Two-way ANOVA determined in the cerebellum/brain stem that IL-6 showed significant main effects of sex (p < 0.001) and treatment (p < p < 0.04) but not interaction (p = 0.14). Pairwise comparisons were assessed using a Fisher’s LSD test; * indicates p < 0.05 vs. saline group; # indicates p < 0.05 vs. LPS group; Δ indicates p < 0.05 vs. males LPS