Table 2.
Main UCP2 SNPs and their pathological implications in human diseases.
| SNP | Molecular Effects | Clinical Phenotypes | Refs. |
|---|---|---|---|
| -866G>A SNP | |||
| A allele | ↑ UCP2 ↓ROS | [80] | |
| G allele | ↓ UCP2 ⬆ROS | [57] | |
| GG genotype | ↑ plasmatic hs-CRP | ↓ T2DM in obesity | [57, 80] |
| GA genotype | ⬆ myeloperoxidase level | CAD (reduced post-MI survival in T2DM) ⬆Obesity and metabolic abnormalities in NAFLD patients |
[69, 70] [92] |
| AA genotype | ⬆ myeloperoxidase level | Associated with better functional outcome in IS patients after recanalization of proximal MCAO CAD (reduced post-MI survival in T2DM) |
[60] [69, 70] |
| 45 bp Ins/Del | |||
| I/I genotype | Heart rate variability ⬆blood pressure | [71] | |
| D/D genotype | ↑adiponectin level ↓leptin ↓TNFα ↓IL-6 levels after exercise training |
Obesity, MS | [93] |
| Ala55Val SNP C>T | |||
| C allele carriers | ↑Obesity, ↑T2DM | [83] | |
Abbreviations legend: SNP=single nucleotide polymorphism; hs-CRP= high-sensitivity-CRP, CAD=coronary artery disease; T2DM=type 2 diabetes mellitus; NAFLD= non-alcoholic fatty liver disease; MS= metabolic syndrome.