. 2023 Jan 26;2023(1):CD012144. doi: 10.1002/14651858.CD012144.pub3

PRESTIGE‐AF.

Study name	PREvention of STroke in Intracerebral haemorrhaGE survivors with Atrial Fibrillation (PRESTIGE‐AF)
Methods	Design: randomised controlled PROBE parallel group trial Setting: multicentre international in Europe Dates: 3 June 2019 to 30 November 2022
Participants	Sample size: 654 participants Diagnosis: ICH Inclusion criteria: not reported Exclusion criteria: not reported
Interventions	Intervention: DOAC (dabigatran, apixaban, rivaroxaban, or edoxaban) Comparator: no OAC. If the patient is randomized in this arm investigators will use their best judgment to decide upon the prescription of an antiplatelet drug of their choice or no such therapy
Outcomes	Primary outcomes Ischaemic stroke Recurrent ICH Secondary outcomes All stroke Systemic embolism Major adverse cardiac events All‐cause mortality Rate of cardiovascular mortality Major haemorrhage Intracranial haemorrhage All strokes, systemic embolic event, myocardial infarction, cardiovascular mortality and major bleeding Myocardial infarction Major bleeding Quality of life (EQ‐5D‐3L) Cognitive function: the Montreal Cognitive Assessment (MoCA) Psychological morbidity: the Hospital Anxiety and Depression Scale (HADS) Duration of follow‐up: 3 years
Starting date	3 June 2019
Contact information	Kirsten H Harvey hello@prestige-af.org;  kirsten.harvey@imperial.ac.uk
Notes	Declarations of interest: not specified in trials register Sources of funding: EU Horizon 2020

AF: atrial fibrillation AVM: arteriovenous malformation CCA: common carotid artery cSAH: convexity subarachnoid hemorrhage CT: computed tomography DBP: diastolic blood pressure DOAC: direct oral anticoagulant ICH: intracerebral haemorrhage IVH: intraventricular haemorrhage LAAO: left atrial appendage occlusion MRI: magnetic resonance imaging mRS: modified Rankin Scale NOAC: novel oral anticoagulant NSAID: non‐steroidal anti‐inflammatory drug OAC: oral anticoagulation SAH: subarachnoid haemorrhage SBP: systolic blood pressure SDH: subdural haemorrhage TIA: transient ischaemic attack VKA: vitamin K antagonist