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. 2023 Jan 4;17(2):1036–1053. doi: 10.1021/acsnano.2c07439

Figure 8.

Figure 8

(a) Flow cytometry analysis of RAW 264.7 cells incubated with 100 μg/mL R-BSA@PSiNPs, 100 μg/mL BSA@PSiNPs, or 100 μg/mL PSiNPs for 12 h after the staining of JC-1 probes; (b) respiratory chain activity, (c) mitochondrial ROS, and (d) cytosolic ROS production of RAW 264.7 cells treated with 100 μg/mL R-BSA@PSiNPs, 100 μg/mL BSA@PSiNPs, or 100 μg/mL PSiNPs for 12 h. Untreated RAW 264.7 cells as a control and ones stimulated by LPS + IFN-γ as a positive control (n = 4 biological independent samples). Error bars are based on standard errors of the mean (***P < 0.001 or *P < 0.05 by ANOVA with Tukey’s post-test).