Table 6.

Association of Systemic Inflammation Blood Indexes and the Femoral Neck BMD by Menopausal Status Group

	Quartile Median Value	Menopausal Status Groupa
		Perimenopause				Postmenopause
		Number of Women (n=181)	Mean BMD (SD) (g/cm2)b	β(SE)c	P	Number of Women (n=390)	Mean BMD (SD) (g/cm2)b	β(SE)c	P
AISId		Total	0.871 (0.108)			Total	0852 (0.108)
Q1	53.677	32	0.869 (0.123)	0.021 (0.025)	0.41	111	0.877 (0.114)	0.044 (0.015)	0.004*
Q2	81.431	48	0.895 (0.113)	0.029 (0.022)	0.194	94	0.847 (0.105)	0.015 (0.015)	0.322
Q3	112.174	53	0.871 (0.096)	0.014 (0.022)	0.511	90	0.853 (0.108)	0.020 (0.016)	0.191
Q4	173.54	48	0.850 (0.104)	0(Reference)		95	0.829 (0.099)	0(Reference)
P for trend		0.248				0.015*
NLPRe		Total	0.871 (0.108)			Total	0.852 (0.108)
Q5	0.005	50	0.880 (0.097)	0.024 (0.022)	0.285	93	0.858 (0.098)	0.019 (0.016)	0.231
Q6	0.007	49	0.890 (0.122)	0.041 (0.022)	0.068	94	0.861 (0.111)	0.022 (0.015)	0.153
Q7	0.009	39	0.861 (0.095)	0.014 (0.023)	0.543	104	0.859 (0.114)	0.026 (0.015)	0.078
Q8	0.013	43	0.849 (0.114)	0(Reference)		99	0.832 (0.106)	0(Reference)
P for trend		0.276				0.190
SIIf		Total	0.871 (0.108)			Total	0.852 (0.108)
Q9	226.571	37	0.904 (0.117)	0.060 (0.024)	0.013*	106	0.881 (0.117)	0.052 (0.015)	0.001*
Q10	312.378	47	0.872 (0.102)	0.026 (0.022)	0.248	96	0.857 (0.112)	0.031 (0.016)	0.046*
Q11	397.879	49	0.877 (0.105)	0.031 (0.022)	0.167	94	0.840 (0.097)	0.016 (0.015)	0.295
Q12	554.510	48	0.839 (0.105)	0(Reference)		94	0.828 (0.097)	0(Reference)
P for trend		0.054				0.004*
SIRIg		Total	0.871 (0.108)			Total	0.852 (0.108)
Q13	0.279	38	0.888 (0.116)	0.034 (0.023)	0.15	106	0.864 (0.098)	0.041 (0.016)	0.009*
Q14	0.394	51	0.871 (0.110)	0.014 (0.022)	0.511	94	0.852 (0.119)	0.034 (0.016)	0.032*
Q15	0.526	44	0.880 (0.107)	0.023 (0.023)	0.306	103	0.873 (0.109)	0.053 (0.015)	0.001*
Q16	0.780	48	0.849 (0.101)	0(Reference)		87	0.814 (0.098)	0(Reference)
P for trend		0.352				0.001*

Notes: ^aMenopausal status. ^bUnadjusted mean BMD (SD) (not transformed). ^cMean BMD values were transformed (negative reciprocal transformation) to improve normality. Results were adjusted for age (years), BMI, FSH, LH, E2, T, TSH, HCY, CRP, HDL, LDL, TG, fasting glucose, and fasting insulin. ^dInteraction with menopausal status: P = 0.021*. ^eInteraction with menopausal status: P = 0.215. ^fInteraction with menopausal status: P = 0.163. ^g Interaction with menopausal status: P = 0.164. *Statistically significant difference.

Abbreviations: AISI, aggregate index of systemic inflammation; NLPR, neutrophils lymphocyte to platelet ratio; SII, systemic immune-inflammation index; SIRI, systemic inflammation response index; BMD, bone mineral density.