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. 2023 Jan 9;16:1110163. doi: 10.3389/fnins.2022.1110163

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Copyright © 2023 Conan, Léon, Caroff, Rollet, Chaïr, Martin, Bihel, Mignen, Voisset and Friocourt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecules reducing the phenotypes induced by CYS4-OE decrease H₂S production. The level of H₂S production and cell viability were assessed using the Azido-4-Methylcoumarin (AzMC) probe and the WST-8 assay, respectively. A 24 h-treatment of HepG2 cells with 9-methylstreptimidone (A), doxorubicin and daunorubicin hydrochloride (B), 8α-hydroxy verrucarin A (C), and chrysomycin A (D), resulted in decreased H₂S production (upper panels) without decreasing cell viability, except at the highest concentrations tested (lower panels). Comparison of each condition with DMSO, one-way ANOVA with Dunnett’s post-hoc test: **p < 0.01; ***p < 0.001, ****p < 0.0001.