TABLE 1.

The molecules identified in the screen share common properties such as metal cation binding or target pro-survival pathways.

Compound	Metal-binding properties	Effect on NF-κ B pathway	Effect on Akt/GSK3β pathway	References
9-Methylstreptimidone	None	Inhibitor	possible inhibitor	Wang et al., 2006; Ishikawa et al., 2009; Brassesco et al., 2012; Koide et al., 2015
4-(2-Thiazolylazo)-resorcinol	Cu(II)			Stanley and Cheney, 1966
1-(2-Thiazolylazo)-2-naphtol	Cu(II)			Pease and Williams, 1959
Zinc pyrithione	Zn(II)	Inhibitor		Kim et al., 1999; Ding and Lind, 2009
N,N- dimethyldaunomycin hydrochloride	Cu(II)	Inhibitor		Malatesta et al., 1987; Boland et al., 1997; Ho et al., 2005; Jabłoñska-Trypuæ et al., 2017
Doxorubicin dihydrochloride
Daunorubicin hydrochloride
γ-thujaplicin	Cu(II), Zn(II)	Inhibitor	Inhibitor	MacLean and Gardner, 1956; Miyamoto et al., 1998; Byeon et al., 2008; Huang et al., 2015; Wu et al., 2020
Verrucarin A,10-epoxide		Inhibitor	Inhibitor	Deeb et al., 2016; Liu et al., 2016
8α-Hydroxy-verrucarin A
Monoacetyl verrucarin A epoxide
Chrysomycin A		Inhibitor	Inhibitor	Liu et al., 2021, 2022
Naphtoquinones	Cu(II)	Inhibitor		Brandelli et al., 2004; Golan-Goldhirsh and Gopas, 2014