Appendix 1.
Tests for Absolute Differences in Health Measures Between Successive Numbers of COPCs
| Health measures z score |
Linear association |
EST (SE), P for phenotype z score contrast of: |
||||
|---|---|---|---|---|---|---|
| β (SE), P | 1 vs 0 | 2 vs 0 | 3 vs 0 | 4 vs 0 | 5 vs 0 | |
| PROMIS fatigue score | 0.28 (0.04), < .01 | 0.31 (0.11), < .01 | 0.46 (0.14), < .01 | 1.00 (0.13), < .01 | 0.92 (0.30), < .01 | 1.83 (0.19), < .01 |
| PSQI | 0.32 (0.03), < .01 | 0.47 (0.10), < .01 | 0.70 (0.12), < .01 | 1.01 (0.13), < .01 | 1.31 (0.19), < .01 | 1.19 (0.33), < .01 |
| OSA symptomsa | 8.2 ( 1.9), < .01 | 10.9 (5.5), .04 | 16.5 (6.4), < .01 | 17.0 (7.0), .01 | 41.6 (16.3), .01 | 35.5 (21.2), .09 |
| Sum of atopic disorders | 0.12 (0.04), < .01 | 0.32 (0.11), < .01 | 0.25 (0.11), .02 | 0.39 (0.20), .04 | 0.16 (0.27), .54 | 0.96 (0.33), < .01 |
| BMI (kg/m2) | 0.05 (0.05), .35 | −0.13 (0.13), .32 | 0.09 (0.15), .53 | 0.08 (0.17), 0.61 | 0.57 (0.46), .21 | −0.13 (0.32), .68 |
Est = estimated mean difference; SE = standard error; PROMIS = Patient-Reported Outcomes Measurement Information System Fatigue Short Form; PSQI = Pittsburgh Sleep Quality Index; OSA = obstructive sleep apnea; BMI = body mass index.
a
Health measure is binary (not z score); lower 95% confidence limit is for the ratio difference (%) of health measure between successive numbers of COPCs.