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. Author manuscript; available in PMC: 2023 Jan 26.
Published in final edited form as: Acta Mater Med. 2022 Dec 30;1(4):552–562. doi: 10.15212/amm-2022-0024

Figure 1. The interaction of osteosarcoma and related cells through exosomes.

Figure 1.

The MSCs, CAFs, and CSCs secrete exosomes containing specific proteins and genetic materials to promote the proliferation, metastasis, and invasion of osteosarcoma. Meanwhile, osteosarcoma cells generate exosomes targeting specific cells to promote angiogenesis, osteoclastogenesis, and immunomodulation of the supporting cells. Osteosarcoma promotes drug resistance, proliferation, and metastasis through exosome secretion. (Created in Biorender.com)