Fig 1. eNOS activation is impaired in endothelial cells from individuals who use pod-based e-cigarettes to a similar degree as combustible cigarette use.

Ser-1177 phosphorylation was compared between the unstimulated and acetylcholine stimulated endothelial cells and evaluated as a percentage change. Data are plotted as individual measurements for each participant, mean and standard error of the mean compared by ANOVA with Tukey post-hoc testing for between group comparisons. Cigarette = combustible cigarette.