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. 2023 Jan 26;18(1):e0278844. doi: 10.1371/journal.pone.0278844

Fig 6. Smooth muscle cell (SMC) differentiation is impaired by miR-130b overexpression and TSC1 repression.

Fig 6

(A) Phase contrast images showing TXA2-mediated myogenic differentiation (t = 4 d) of primary hMSCs transfected with mimic control (SCR), miR-130b and siRNA targeting TSC1 (siTSC1). (B) Relative mRNA levels of the SMC marker SMMHC, and TSC1 at the 4 d endpoint following miR-130b transfection. (C) Relative mRNA levels of SMMHC at the 4 d endpoint following siTSC1 transfection. Values are normalized to control SCR levels prior to myogenic induction (t = -1 d). Data are representative of 3 independent experiments. Scale bar: 100 μm.