Table 2. Investigating the contributions of substructure-attention mechanism and co-attention layer.

	ACC	AUC	F1	Prec	Rec	AUPR
DGNN-DDI_no_SA	0.9072	0.9482	0.8979	0.8833	0.9155	0.9248
DGNN-DDI_no_CA	0.8882	0.9461	0.8915	0.8755	0.9413	0.9313
DGNNDDI_no_SA_CA	0.8858	0.9445	0.8898	0.8785	0.9308	0.9273
DGNN-DDI	0.9609	0.9894	0.9616	0.9472	0.9788	0.9863