Table 2: Cox model with hazard ratios and 95% confidence intervals for mortality associated with covariates, among patients with Ewing’s sarcoma of bones and joints.
| Variable | Crude | Adjusted* | ||||
|---|---|---|---|---|---|---|
| HR | (95% CI) | P-value | HR | (95% CI) | P-value | |
| Sex | ||||||
| Female | 1 | (reference) | 1 | (reference) | ||
| Male | 1,47 | (1.12-1.93) | < 0.05 | 1.19 | (0.98-1.71) | 0.074 |
| Age | ||||||
| < 18 years | 1 | (reference) | 1 | (reference) | ||
| ≥ 18 years | 1,89 | (1.47-2.44) | < 0.05 | 1.77 | (1.38-2.31) | < 0.05 |
| Race | ||||||
| White | 1 | (reference) | 1 | (reference) | ||
| Black | 1.68 | (1.27-2.07) | < 0.05 | 1.52 | (1.37-1.86) | 0.075 |
| Other | 0.63 | (0.49-1.53) | 0.38 | 0.91 | (0.68-1.74) | 0.84 |
| Tumor site | ||||||
| Extremity | 1 | (reference) | 1 | (reference) | ||
| Spine and pelvis | 2.57 | (1.74-2.79) | < 0.05 | 2.03 | (1.31-2.62) | < 0.05 |
| Tumor grade | ||||||
| Low | 1 | (reference) | 1 | (reference) | ||
| High | 2.37 | (0.77-4.29) | 0.81 | - | - | - |
| Tumor size | ||||||
| ≤ 10 cm | 1 | (reference) | 1 | (reference) | ||
| > 10 cm | 2.01 | (1.46-2.77) | < 0.05 | 1.78 | (1.34-2.56) | < 0.05 |
| Treatment | ||||||
| Radiotherapy with surgery | 1 | (reference) | 1 | (reference) | ||
| Surgery alone | 0.61 | (0.42-0.92) | < 0.05 | 0.51 | (0.38-0.89) | < 0.05 |
| Radiotherapy alone | 1.66 | (1.24-2.51) | < 0.05 | 1.61 | (1.10-2.39) | < 0.05 |
| None | 2.27 | (1.53-3.38) | < 0.05 | 1.86 | (1.23-2.58) | < 0.05 |
HR = hazard ratio; CI = confidence interval. *Adjusted for sex, age, race, tumor site, tumor size and treatment.