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. 2022 Dec 26;14(12):e32970. doi: 10.7759/cureus.32970

Table 1. Baseline characteristics of spontaneous regression within the study sample.

Patient characteristics* Oral (n=46) Esophageal (n=11) Gastric (n=38) Peritoneal (n=3) Hepatobiliary (n=212) Pancreatic (n=10) Small bowel (n=10) Colorectal  (n=60) Total (n=390)
Age (Mean (SD)) 61.2 (17.4) 59.0 (16.2) 60.1 (19.0) 47.7 (15.9) 64.7 (13.5) 50.4 (18.2) 51 (16.2) 62.1 (15.0) 63.1 (14.7)
Age group (n (%))                  
<19 1 (2.2%) 0 1 (2.6%) 0 0 0 0 1 (1.7%) 3 (0.8%)
19-34 3 (6.5%) 1 (9.1%) 2 (5.3%) 0 6 (2.8%) 2 (20.0%) 1 (10.0%) 1 (1.7%) 16 (4.1%)
35-44 1 (2.2%) 1 (9.1%) 7 (18.4%) 2 (66.7%) 6 (2.8%) 1 (10.0%) 2 (20.0%) 7 (11.7%) 27 (6.9%)
45-54 11 (23.9%) 1 (9.1%) 2 (5.3%) 0 21 (9.9%) 1 (10.0%) 1 (10.0%) 7 (11.7%) 44 (11.3%)
55-64 8 (17.4%) 4 (36.4%) 10 (26.3%) 0 49 (23.1%) 2 (20.0%) 5 (50.0%) 17 (28.3%) 95 (24.4%)
65-74 9 (19.6%) 2 (18.2%) 5 (13.2%) 1 (33.3%) 82 (38.7%) 1 (10.0%) 1 (10.0%) 13 (21.7%) 114 (29.2%)
75-84 11 (23.9%) 2 (18.2%) 10 (26.3%) 0 43 (20.3% 1 (10.0%) 0 12 (20.0%) 79 (20.3%)
85+ 2 (4.3%) 0 1 (2.6%) 0 4 (1.9%) 0 0 2 (3.3%) 9 (2.3%)
Sex (n (%))                  
Male 25 (54.3%) 8 (72.7%) 23 (60.5%) 2 (66.7%) 168 (79.2%) 6 (60.0%) 5 (50.0%) 35 (58.3%) 272 (69.7%)
Female 21 (45.7%) 3 (27.3%) 15 (39.5%) 1 (33.3%) 44 (20.8%) 4 (40.0%) 5 (50.0%) 25 (41.7%) 118 (30.3%)
Site of Regression (n (%))                  
Primary tumor/Recurrence 41 (89.1%) 8 (72.7%) 35 (92.1%) 0 194 (91.5%) 10 (100.0%) 7 (70.0%) 48 (80.0%) 288 (73.8%)
Lung metastases 2 (4.3%) 3 (27.3%) 0 1 (33.3%) 28 (13.2%) 0 1 (10.0%) 2 (3.3%) 37 (9.5%)
Liver metastases 0 0 1 (2.6%) 1 (33.3%) 2 (0.9%) 2 (20.0%) 2 (20.0%) 10 (16.7%) 18 (4.6%)
Lymph metastases 5 (10.9%) 2 (18.2%) 1 (2.6%) 0 2 (0.9%) 0 3 (30.0%) 2 (3.3%) 15 (3.8%)
Other metastases 1 (2.2%) 1 (9.1%) 1 (2.6%) 1 (33.3%) 13 (6.1%) 0 1 (10.0%) 6 (10.0%) 24 (6.2%)
Extent of regression (n (%))                  
Complete 43 (93.5%) 9 (81.8%) 32 (84.2%) 2 (66.7%) 156 (73.6%) 8 (80.0%) 10 (100.0%) 57 (95.0%) 317 (81.3%)
Partial 3 (6.5%) 2 (18.2%) 6 (15.8%) 1 (33.3%) 56 (26.4%) 2 (20.0%) 0 3 (5.0%) 73 (18.7%)
Histological profile (n (%))                  
Carcinoma 11 (23.9%) 8 (72.7%) 8 (21.1%) 0 198 (93.4%) 9 (90.0%) 1 (10.0%) 54 (90.0%) 289 (74.1%)
Primary lymphoma 28 (60.9%) 1 (9.1%) 24 (63.2%) 0 4 (1.9%) 0 6 (60.0%) 4 (6.7%) 67 (17.2%)
NET 1 (2.2%) 0 6 (15.8%) 0 2 (0.9%) 1 (10.0%) 1 (10.0%) 1 (1.7%) 12 (3.1%)
Other 6 (13.0%) 2 (18.2%) 0 3 (100.0%) 8 (3.8%) 0 2 (20.0%) 1 (1.7%) 22 (5.6%)
Period of regression (n (%))                  
<1 month 4 (8.7%) 0 3 (7.9%) 0 6 (2.8%) 0 0 0 13 (3.3%)
1-1.5 months 3 (6.5%) 1 (9.1%) 5 (13.2%) 0 11 (5.2%) 1 (10.0%) 0 9 (15.0%) 30 (7.7%)
2-5 months 2 (4.3%) 2 (18.2%) 6 (15.8%) 1 (33.3%) 27 (12.7%) 0 3 (30.0%) 13 (21.7%) 54 (13.8%)
6-11 months 6 (13.0%) 3 (27.3%) 3 (7.9%) 0 16 (7.5%) 1 (10.0%) 3 (30.0%) 1 (1.7%) 33 (8.5%)
12-23 months 6 (13.0%) 2 (18.2%) 5 (13.2%) 0 41 (19.3%) 2 (20.0%) 0 9 (15.0%) 65 (16.7%)
24-35 months 6 (13.0%) 1 (9.1%) 4 (10.5%) 1 (33.3%) 30 (14.2%) 1 (10.0%) 0 3 (5.0%) 46 (11.8%)
36-47 months 5 (10.9%) 0 2 (5.3%) 0 14 (6.6%) 1 (10.0%) 1 (10.0%) 5 (8.3%) 28 (7.2%)
48 months+ 8 (17.4%) 1 (9.1%) 8 (21.1%) 1 (33.3%) 33 (15.6%) 4 (40.0%) 2 (20.0%) 17 (28.3%) 74 (19.0%)
Unspecified 6 (13.0%) 1 (9.1%) 2 (5.3%) 0 34 (16.0%) 0 1 (10.0%) 3 (5.0%) 47 (12.1%)
Malignancy recurrence (n (%))                  
Reported 5 (10.9%) 0 1 (2.6%) 0 14 (6.6%) 1 (10.0%) 2 (20.0%) 1 (1.7%) 24 (6.2%)
Not reported 41 (89.1%) 11 (100.0%) 37 (97.4%) 3 (100.0%) 198 (93.4%) 9 (90.0%) 8 (80.0%) 59 (98.3%) 366 (93.8%)