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. 2022 Dec 12;18(1):42–48. doi: 10.1038/s41565-022-01260-8

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — (a) 2D projection of the tSNE analysis showing lck⁺ lymphocytes (cluster 6) and the cluster corresponding to the liver and pancreas (cluster 14) which is noticeably expanded in the GO+ BA fish. Below are the feature plots showing the expression of genes involved in lipid metabolism (apoda.2) and proteolysis (ela3l, ela2l, ela2, ctrb1, prss1, prss59.1, prss59.2), respectively, in the GF control samples (b,d) versus GO+BA samples (c,e).