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. 2022 Dec 17;14:100087. doi: 10.1016/j.nbscr.2022.100087

Fig. 4.

Fig. 4

Experiment 3: Persistent effects of ELSD on sleep duration are sex specific and age dependent. A-C) There were no significant effects of ELSD on adult sleep fragmentation metrics including arousal index (A), average NREM bout duration (B), or average REM bout duration (C) over 24 h. D) Adult females spent less time in wake than males. E) ELSD females spent more time in NREM sleep than Control females during adulthood and F) male ELSD voles spent less time in REM sleep than age and sex matched controls. Adult females spent more time in REM than adult males and have more consolidated NREM sleep (B). Sleep and wake metrics were totaled over 24 h of EEG/EMG recordings. Note y-axis limit is different on each panel. *p < 0.05 or p < 0.025 (after Bonferroni correction); ***p < 0.001; # 0.05 > p > 0.025 (p value of 0.025 required for statistical significance after Bonferroni correction). number at bottom of bar is sample size for each group, bar height is mean, error bars ± SEM.