Table 1.
Genotype and allele frequencies for CYP3A4, CYP3A5, CYP2C9, CYP2C19 and CYP2J2 in the study population.
| Variant allele | Allele frequency (%) | Genotype frequency N (%) |
|
|---|---|---|---|
| CYP3A4 *1B | 72.0 | *1/*1 | 36 (7.8) |
| *1/*1B | 187 (40.5) | ||
| *1B/*1B | 239 (51.7) | ||
| CYP3A5 *3 | 18.2 | *1/*1 | 311 (67.3) |
| *1/*3 | 134 (29.0) | ||
| *3/*3 | 17 (3.7) | ||
| CYP3A5 *6 | 20.0 | *1/*1 | 294 (63.6) |
| *1/*6 | 151 (32.7) | ||
| *6/*6 | 17 (3.7) | ||
| CYP3A5 *7 | 10.8 | *1/*1 | 369 (79.9) |
| *1/*7 | 86 (18.6) | ||
| *7/*7 | 7 (1.5) | ||
| CYP2C9 *2 | 0.2 | *1/*1 | 460 (99.6) |
| *1/*2 | 2 (0.4) | ||
| *2/*2 | 0 (0) | ||
| CYP2C9 *3 | 0.2 | *1/*1 | 460 (99.6) |
| *1/*3 | 2 (0.4) | ||
| *3/*3 | 0 (0) | ||
| CYP2C19 *2 | 12.4 | *1/*1 | 355 (76.8) |
| *1/*2 | 99 (21.4) | ||
| *2/*2 | 8 (1.7) | ||
| CYP2C19 *3 | 0.1 | *1/*1 | 461 (99.8) |
| *1/*3 | 1 (0.2) | ||
| *3/*3 | 0 (0) | ||
| CYP2C19 *17 | 20.2 | *1/*1 | 291 (63.0) |
| *1/*17 | 155 (33.6) | ||
| *17/*17 | 16 (3.4) | ||
| CYP2J2*7 | 13.4 | *1/*1 | 345 (74.7) |
| *1/*7 | 110 (23.8) | ||
| *7/*7 | 7 (1.5) | ||