Table 3.
Factors associated with plasma praziquantel concentration (ng/mL).
| Variable | Crude Log mean difference (95% CI) | p-value | Adjusted Log mean difference (95% CI) | p-value | |
|---|---|---|---|---|---|
| Sex | Female | Ref. | |||
| Male | 0.032 (− 0.081 to 0.145) | 0.58 | |||
| Age | 0.042 (0.017 to 0.066) | 0.001 | 0.007 (− 0.033 to 0.047) | 0.73 | |
| Weight (kg) | 0.012 (0.006 to 0.018) | < 0.001 | 0.007 (− 0.006 to 0.021) | 0.30 | |
| Height (cm) | 0.008 (0.004 to 0.012) | < 0.001 | 0.002 (− 0.008 to 0.012) | 0.64 | |
| Wasting status (BAZ) | Not wasted | Ref. | |||
| Wasted | − 0.224 (− 0.552 to 0.105) | 0.18 | |||
| Stunting status (HAZ) | Not Stunted | Ref. | |||
| Stunted | − 0.025 (− 0.141 to 0.092) | 0.67 | |||
| CYP3A4 | *1/*1 | Ref. | |||
| *1B carriers | 0.040 (− 0.171 to 0.250) | 0.71 | |||
| CYP3A5 | *1/*1 | Ref. | |||
| *3, *6, *7 carriers | 0.075 (− 0.053 to 0.204) | 0.25 | |||
| CYP2C9 | *1/*1 | Ref. | Ref. | ||
| *2, *3 carriers | 0.635 (0.028 to 1.241) | 0.04 | 0.540 (− 0.056 to 1.134) | 0.08 | |
| CYP2J2 | *1/*1 | Ref. | |||
| *7 carriers | 0.035 (− 0.095 to 0.165) | 0.60 | |||
| CYP2C19 | *1/*1 (EM) | Ref. | Ref. | ||
| *2, *3 carriers (IM&PM) | 0.188 (0.046 to 0.330) | 0.01 | 0.185 (0.045 to 0.326) | 0.01 | |
| *17 (*1/*17 or *17/*17) (UM) | − 0.010 (− 0.229 to 0.030) | 0.13 | − 0.080 (− 0.208 to 0.048) | 0.22 | |
BAZ body mass index (BMI) for age Z score, EM extensive metabolizers, HAZ height for Age Z score, PZQ praziquantel, IM intermediate metabolizers, UM ultrarapid metabolizers.
Significant values are in bold.