Table 4.
Risk factors for T-cell non response.
| Unadjusted model | Adjusted model** | ||||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | OR | 95% CI | P-value | ||
| Age per ten years | 1.1 | 0.84-1.5 | 0.490 | 1.1 | 0.82-1.5 | 0.531 | |
| Female sex | 1.4 | 0.75-2.6 | 0.295 | 1.3 | 0.68-2.5 | 0.425 | |
| Transplantation type (Liver Tx as reference) | |||||||
| - Kidney - Lung |
0.75 1.5 |
0.38-1.5 0.61-3.5 |
0.412 0.395 |
0.72 1.4 |
0.35-1.5 0.55-3.4 |
0.359 0.509 |
|
| Time from transplantation to first vaccine dose | 0.97 | 0.93-1.02 | 0.195 | 0.98 | 0.93-1.02 | 0.298 | |
| Number of vaccines before the infection (Three doses as reference) | |||||||
| - Four | 0.82 | 0.32-2.1 | 0.672 | 0.99 | 0.37-2.7 | 0.988 | |
| Time from last vaccine dose (more than 120 days as reference) | 1.3 | 0.64-2.5 | 0.497 | – | – | – | |
| SARS-CoV-2 infection prior to 12th month-sample | 0.84 | 0.42-1.7 | 0.618 | 0.86 | 0.41-1.8 | 0.673 | |
| Immunosuppressive treatment | |||||||
| Antimetabolite (None as reference) | |||||||
| - Mycophenolate - Azathioprine |
1.02 1.2 |
0.45-2.3 0.37-3.1 |
0.955 0.804 |
- - |
- - |
- - |
|
| Corticosteroids | 1.7 | 0.79-1.7 | 0.120 | – | – | – | |
|
CNI or mTOR
(CNI as reference) |
0.69 | 0.25-1.9 | 0.465 | – | – | – | |
| mTOR | |||||||
| Comorbidities | |||||||
| Cardiovascular disease | 1.2 | 0.65-2.4 | 0.523 | – | – | – | |
| Diabetes mellitus | 2.4 | 1.05-5.3 | 0.038 | 2.4 | 1.02-5.5 | 0.044 | |
**Adjusted for age, sex, transplant type, time from transplantation, number of vaccine doses, prior infection and diabetes mellitus. P-values for the bold values were <0.05 (statistically significant).