Figure 6.

hetIL-15 alone or in combination with doxorubicin cures the resected mice and facilitates the development of tumor-specific immunological memory. (A) Survival curves for the animals in each experimental group. Mice were resected and treated following the therapeutic schedule shown in Figure 5A . Data merged from two independent studies (n=9-16). Statistical analysis was done by Log-rank (Mantel-Cox) test. (B) Tumor growth curves of naive and survivor animals [hetIL-15 and combination group mice merged from (A)] after rechallenge with 5x10⁴ 4T1 cells without any treatment until day 19. Tumor volume (mm³) ± SEM for each time point is shown. Statistical analysis was done by two-way ANOVA (n=9-10). **p < 0.01, ****p < 0.0001, SEM, standard error of the mean.