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. 2023 Jan 21;28:100594. doi: 10.1016/j.bbih.2023.100594

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 1 — IL-1β enhances the intrinsic excitability of mPFC pyramidal cells in brain slices. (A) Representative traces showing the baseline, treatment, and washout firing pattern of three mPFC pyramidal cells treated with ACSF, IL-1β (20 ng/ml), and IL-1β (20 ng/ml) together with IL-1Ra (80 ng/ml). (B) The percentage changes of the investigated parameters (n = 7–9 cells from 3 to 6 animals for each group). The threshold potential of the first spike showed a significant decrease during the treatment with 20 ng/ml IL-1β. However, this decrease was not significant compared to the slight changes induced by the control (ACSF) and combined (IL-1β + IL-1Ra) treatments (upper panel). Firing frequency showed a concentration-dependent increase induced by 1 ng/ml and 20 ng/ml IL-1β, which could be abolished by the co-application of IL-1Ra (middle panel). The latency of the first spike gradually decreased with the increasing concentrations of IL-1β, which was also prevented by IL-1Ra (lower panel). All observed changes were found to be irreversible during the 10 min washout period. One-way (#) and one-way repeated measures (*) ANOVA followed by Tukey post hoc test. Data are shown as mean ± SD. #, *P < 0.05; **P < 0.01; ***P < 0.001; n.s. not significant.