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. 2023 Jan 21;28:100594. doi: 10.1016/j.bbih.2023.100594

Fig. 5.

Fig. 5

The upregulation of IL-1β and IL-1R1 after LPS treatment shows a similar time course as the neuroinflammation-related EEG changes. (A) The concentration of IL-1β measured in PFC tissue homogenates at different time points after LPS injection. The data show a significant increase 4 h after the treatment and then a rapid decrease. (B) Serum levels of IL-1β also showed a significant increase 4 h after LPS injection; however, the following decrease was more gradual over time. The concentration of IL-1β was measured by a magnetic bead-based immunoassay. (C) Western blot analysis of PFC IL-1R1 expression after LPS treatment. Densitometry analysis of immunoblots from PFC tissue homogenates (left panel) revealed a significant increase in IL-1R1 levels at 4 h after LPS treatment and then a gradual decrease over time (right panel). Control and 4 h LPS data were statistically compared using two-sample t-test (n = 5 mice for each group). Data are presented as mean ± SD. *P < 0.05, **P < 0.01.