Table 2.
Alterations of retinal and choroidal microvascular density detected by OCTA in multiple sclerosis patients with or without optic neuritis.
| Outcome variables | No. of studies | No. of eyes | Weighted mean difference (95% CI) | P-value | I2 test | Egger's test |
|---|---|---|---|---|---|---|
| SVC density (%) | ||||||
| MSNON vs. HC | 11 | 1188 | −2.27 (−3.12, −1.43) | < 0.01** | 72.79% | 0.19 |
| MSON vs. HC | 9 | 924 | −4.30 (−5.27, −3.33) | < 0.01** | 62.90% | 0.85 |
| MSON vs. MSNON | 9 | 688 | −2.17 (−3.11, −1.22) | < 0.01** | 52.19% | 0.61 |
| DVC density (%) | ||||||
| MSNON vs. HC | 9 | 812 | −0.79 (−2.05, 0.46) | 0.21 | 78.11% | 0.99 |
| MSON vs. HC | 7 | 652 | −0.62 (−2.99, 1.74) | 0.60 | 91.28% | 0.54 |
| MSON vs. MSNON | 7 | 502 | −0.21 (1.32, 0.89) | 0.71 | 50.73% | 0.71 |
| Peripapillary vessel density (%) | ||||||
| MSNON vs. HC | 8 | 713 | −2.82 (−4.57, −1.07) | < 0.01** | 89.71% | 0.02* |
| MSON vs. HC | 6 | 534 | −4.96 (−8.95, −0.97) | < 0.01** | 96.63% | 0.34 |
| MSON vs. MSNON | 7 | 444 | −2.02 (−3.67, −0.36) | < 0.01** | 70.61% | 0.34 |
| Choriocapillaris density (%) | ||||||
| MSNON vs. HC | 4 | 327 | 1.44 (−0.34, 3.21) | 0.11 | 82.98% | < 0.01** |
| MSON vs. HC | 2 | 215 | 5.59 (−3.79, 14.98) | 0.24 | 95.95% | 0.49 |
| MSON vs. MSNON | 2 | 174 | 0.62 (−0.21, 1.44) | 0.14 | < 0.01% | 0.69 |
*
P < 0.05,
**
P < 0.01.