Figure 3.

Whole-brain-scale simulations of connected AdEx mean-field models produce activity mimicking wake- and sleep-like states. Time variation of firing rates (ν_e,i, top) and adaptation currents (W_e, bottom) in simulated wake- (A) and sleep-like (B) states for each of the model nodes representing 68 brain regions. When adaptation (b_e) equals 0 pA, the activity of model nodes is asynchronous (A), whereas the inclusion of adaptation (b_e = 60 pA) leads to the emergence of synchrony between brain regions (B). (C) Fourier power spectra of signals produced by the TVB-AdEx in synchronous (sleep-like) and asynchronous (wake-like) states for different values of b_e. Note that maximal power in the sleep-like condition falls in the delta range (1–4 Hz), while it occurs near 10 Hz, in the alpha range for low adaptation, wake-like states.