Table 3. Comparison of patients with aortic stenosis with and without complications or minor symptoms during dobutamine stress cardiac magnetic resonance imaging.
| Variables | Patients with complications/minor symptoms (n = 19) | Patients without complications/minor symptoms (n = 76) | p | ||
|---|---|---|---|---|---|
| Demographics | |||||
| Age (years) | 80 ± 5 | 74 ± 9 | 0.015* | ||
| Male sex | 16 (84) | 65 (84) | 0.886 | ||
| BMI (kg/m2) | 28 (25–29) | 27 (24–30) | 0.787 | ||
| NYHA stage | 0.588 | ||||
| 1 | 5 (26) | 22 (29) | |||
| 2 | 7 (37) | 30 (40) | |||
| 3 | 6 (32) | 23 (30) | |||
| 4 | 0 (0) | 0 (0) | |||
| n.a. | 1 (5) | 1 (1) | |||
| Cardiovascular risk factors | |||||
| Hypertension | 18 (95) | 71 (93) | 0.834 | ||
| Hypercholesterolemia | 18 (95) | 49 (64) | 0.010* | ||
| Diabetes mellitus | 6 (32) | 34 (45) | 0.301 | ||
| History of Smoking | 4 (21) | 29 (38) | 0.164 | ||
| Family history of coronary artery disease | 6 (32) | 13 (17) | 0.161 | ||
| Comorbidities | |||||
| Coronary artery disease | 18 (95) | 73 (96) | 0.659 | ||
| Prior myocardial infarction | 9 (47) | 29 (38) | 0.466 | ||
| Prior percutaneous coronary intervention | 13 (68) | 43 (57) | 0.351 | ||
| Prior coronary artery bypass grafting | 9 (47) | 18 (24) | 0.042* | ||
| Prior stroke | 5 (26) | 5 (7) | 0.013* | ||
| COPD | 4 (21) | 9 (12) | 0.299 | ||
| Laboratory data | |||||
| High sensitive troponin T (pg/mL) | 52 (28–216) | 27 (14–69) | 0.018* | ||
| NT-proBNP (ng/L) | 1,780 (847–3,202) | 1,266 (464–4,404) | 0.724 | ||
| GFR (mL/min/1.73m2) | 65 (49–79) | 69 (44–85) | 0.281 | ||
| Cardiac morphology | |||||
| LV-EF (%) | 57 (42–63) | 52 (40–61) | 0.443 | ||
| LV-EDV (mL) | 182 (125–206) | 180 (152–215) | 0.545 | ||
| Heart rate (bpm) | 67 ± 11 | 67 ± 14 | 0.741 | ||
| BP systolic (mmHg) | 133 ± 24 | 130 ± 19 | 0.542 | ||
| BP diastolic (mmHg) | 63 ± 13 | 67 ± 11 | 0.052 | ||
| AVA (cm2) | 1.2 (1.1–1.3) | 1.2 (1.0–1.3) | 0.910 | ||
| PPG (mmHg) | 35 (24–45) | 34 (23–45) | 0.810 | ||
| MPG (mmHg) | 20 (14–27) | 19 (14–26) | 0.696 | ||
| Inducible ischemia (positive stress CMR) | 12 (63) | 20 (26) | 0.003† | ||
Comparison of patients with aortic stenosis with and without complications during dobutamine stress cardiac magnetic resonance imaging. Values are mean ± SD, median (interquartile range) or number (%). Differences were calculated using t-test, Mann-Whitney U test or χ2 test.
AVA: aortic valve area, BMI: body mass index, BP: blood pressure, bpm: beats per minute, CMR: cardiac magnetic resonance, COPD: chronic obstructive pulmonary disease, EDV: end-diastolic volume, EF: ejection fraction, GFR: glomerular filtration rate, LV: left ventricle, NT-proBNP: N-terminal pro B-type natriuretic peptide, NYHA: New York Heart Association functional classification, PPG: peak pressure gradient.
*p < 0.05; †p < 0.01.