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γ/δ TCR KO mice die after infection with a dose of Listeria cells that intact C57BL/6 (B6 control) mice are able to resist. Listeria cells (L.m.; 5 × 105 CFU) were injected i.p. into B6 control or γ/δ TCR KO mice (five mice/group), and survival was monitored daily. For comparison, a group of B6 control mice received a 10-fold higher dose (5 × 106 CFU). Results were confirmed in C3HeB/FeJ mice immunodepleted of γ/δ T cells (not shown).
