FIG. 3.

Systemic proinflammatory cytokine responses to Listeria infection in B6 control (n = 11), α/β TCR KO (n = 5), γ/δ TCR KO (n = 12), RAG-1 KO (n = 7), and IL-12 KO (n = 6) mice. Cytokines in peritoneal lavage fluid collected from individual mice 48 h after i.p. infection with 1.3 × 10⁴ CFU of Listeria were measured by ELISA. Means for each group are shown as vertical lines and as numerical values on the right. Circles, values from individual mice. Statistically significant differences from B6 controls are indicated (asterisk, P < 0.05; double asterisk, P < 0.01; unpaired t test). These cytokines were undetectable in fluids from uninfected mice.