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. 2023 Jan 13;13:1089987. doi: 10.3389/fimmu.2022.1089987

Figure 4.

Figure 4

AID reduces the Teff/Treg cell ratio in the pancreatic lymph nodes and islets of NOD mice. (A, B): Representative flow cytometry plots (Left) and percentage (Right) of INFγ+CD4+(Th1), IL-17+CD4+ (Th17) and INF-γ+IL-17+CD4+ (DP Th1/17 cells) cells out of total CD4+ T cells in pancreatic lymph nodes (PLN) (A) and pancreatic intra-islet lymphocytes (IIL) (B) of 12-week-old NOD mice fed with AID or STD diet (n=8 per group). (C, D) Representative flow cytometry plots (Left) and percentage (Right) of FoxP3+CD25+CD4+ (FoxP3+Treg cells) and IL-10+FOXP3-CD4+ (Tr1 cells) cells out of total CD4+ T cells in the PLN (C) and pancreatic IIL (D) of 12-week-old NOD mice fed with AID or STD diet (n=8 per group). All data are presented as mean percentages ± SEM. *p < 0.05; **p < 0.01.