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. Author manuscript; available in PMC: 2023 Jan 27.
Published in final edited form as: Psychoneuroendocrinology. 2022 Jun 30;143:105852. doi: 10.1016/j.psyneuen.2022.105852

Fig. 3.

Fig. 3.

Salivary cf-mtDNA diurnal variation in Participant B. (A) Day-to-day variation of salivary cf-mtDNA, steroid hormones in a 35 year-old male participant (Participant B). (Top) Salivary cf-mtDNA collected at awakening, 30 and 45 min after awakening, and bedtime over 60 consecutive days (n = 220 observations), the arrow indicates a day during which the participant ran a marathon. 60-day diurnal profiles for (B) cortisol and (C) cf-mtDNA (without outliers). (D) Fold change in saliva cortisol from awakening to + 30, awakening to + 45 and morning peak to evening values. (E) Same as in (D) for salivary cf-mtDNA. ((F) Exploratory analyses of the associations between cf-mtDNA levels, mood, and health-related behaviors from the daily diaries collected in the morning and (G) evening. Numbers are the effect sizes (Spearman rho), color-coded by the directionality of the association (blue, negative; red, positive). (H) Selected examples of association shown as scatterplots (numbered 1–4) from F and G. In (B, C) data is shown as means and individual datapoints, p-values from One-way ANOVA for repeated measures (main effect). (D, E) P-values from chi-squared test comparing proportion of positive and negative awakening response compared to chance (50:50). (F) P-values from Spearman’s correlation test, p < 0.05*, p < 0.01**, p < 0.001***, p < 0.0001****.