FIG. 2.
Effect of 6-OHDA treatment on host resistance against L. monocytogenes. (A) Mice were injected with 6-OHDA and were infected with 5 × 105 (□), 5 × 106 (○), or 5 × 107 (●) CFU of L. monocytogenes 48 h later, and the levels of survival were determined for each group of five mice. (B) Mice were injected with 6-OHDA (solid bars) or the vehicle (open bars) and were infected with 5 × 104 CFU of L. monocytogenes 48 h later. The numbers of bacteria in the livers and spleens were determined on days 2 and 5 after infection. Each result is the mean ± standard deviation based on three mice. An asterisk indicates that a value is significantly different from the value obtained for the vehicle-treated mice (P < 0.05). The results were reproduced in three repeated experiments.