Table 1.
List of representative mRNAs with 3’UTR-mediated control
| Transcript | RNA-binding proteins | Control | Function | Reference |
|---|---|---|---|---|
| Hunchback | Pumilio Nanos Brat |
Translation repression | Embryonic axis formation in Drosophila | (Kuersten and Goodwin, 2003) |
| UCP1 | CPEB2 | Translation activation | Maintain body temperature | (Chen et al., 2018) |
| CaMK2A | Mub | Localization translation | Control learning and memory in neuron | (Broix et al., 2021; Chen et al., 2022) |
| ACTB | IGF2BP1 PAT1 |
Stabilization local-translation | Constituent of the cytoskeleton for structural support and movement in neuron | (Wu et al., 2020) |
| Oskar | Bruno Hrp48 |
RNP granule formation Translation |
Embryonic patterning and germline formation in Drosophila | (Bose et al., 2022; Jambor et al., 2014) |
| DMPK | CUG-BP2 | mRNA export Translation |
Maintenance of the myelin sheath | (Amack and Mahadevan, 2001; Taneja et al., 1995) |
|
n-myc
c-fos |
ELAV like RNA binding protein family | ARE-mediated mRNA stabilization | Cellular growth in neuroblastoma | (Chagnovich and Cohn, 1996; Chagnovich et al., 1996) |
| P21 WAF1 | SRSF3 | Translation repression | Regulator of cell cycle and senescence | (Kim et al., 2022) |
| COX-2 | HuR b-catenin |
mRNA stabilization Translation activation |
Cellular proliferation and tumorigenesis | (Kim et al., 2012; Lee and Jeong, 2006) |