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. 2023 Jan 18;46(1):33–40. doi: 10.14348/molcells.2023.2170

Fig. 2. Therapeutic approaches using circular RNA.

Fig. 2

(A) Circular RNAs as therapeutic targets. ICS removal using the CRISPR-Cas9 system at the biogenesis stage and circular RNA knockdown using shRNA, CRISPR-Cas13, and ASO were examined for the downregulation of circular RNAs. (B) Circular RNAs as a therapeutic tool. Highly purified in vitro synthetic circular RNAs can be delivered to cells to function as sponges and play roles in alternative splicing regulation, exogenous protein expression, and microRNA suppression.