Skip to main content
. Author manuscript; available in PMC: 2023 Jan 27.
Published in final edited form as: Nat Immunol. 2022 Jul 28;23(8):1183–1192. doi: 10.1038/s41590-022-01274-3

Figure 4. ICOS+CD38+ cTfh activation state is associated with development of irAE.

Figure 4.

A. aPD1 participants in Cohort 2 were subgrouped based on irAE (Y=Yes, N=No). Differential expression analysis was performed on ICOS+CD38+ cTfh at baseline, and all genes with Padj < 0.05 are shown. B. GSEA for Hallmark gene sets in the setting of irAE. C. Fold-change in cTfh responses after influenza vaccine, calculated as the frequency at one week relative to baseline.