TABLE 1.
Classical categorisation of caspases in mice as in Shalini et al. (2015). Detailed information of functions and molecular signalling and general phenotype of caspase-deficient mice for each caspase is given by individual studies listed in the table.
| Categorisation of caspases in mice | |||
|---|---|---|---|
| Caspase monomer | Caspase reviewed in | Caspase-deficient mice | |
| Apoptotic initiators | |||
| Caspase-2 |
|
Brown-Suedel and Bouchier-Hayes (2020) | Bergeron et al. (1998), Zhang et al. (2007) |
| Caspase-8 |
|
Mandal et al. (2020) | Varfolomeev et al. (1998) |
| Caspase-9 |
|
Li et al. (2017), Avrutsky and Troy (2021) | Kuida et al. (1998) |
| Apoptotic executors | |||
| Caspase-3 |
|
Asadi et al. (2022), Eskandari and Eaves (2022) | Leonard et al. (2002), Lakhani et al. (2006) |
| Caspase-6 |
|
Wang et al. (2015) | Uribe et al. (2012) |
| Caspase-7 |
|
Lamkanfi and Kanneganti (2010) | Lakhani et al. (2006) |
| Inflammatory caspases | |||
| Caspase-1 |
|
Sollberger et al. (2014) | Kuida et al. (1995) |
| Caspase-11 |
|
Agnew et al. (2021) | Wang et al. (1998b) |
| Caspase-12 |
|
Dadley-Moore (2004) | Nakagawa et al. (2000), Skeldon et al. (2016) |
| Others | |||
| Caspase-14 |
|
Denecker et al. (2008) | Denecker et al. (2007), Hoste et al. (2011) |
CARD, caspase recruitment domain; DED, death effector domain; DD, death domain; LS, large subunit; SS, small subunit.