TABLE 2.
Overview of caspase apoptotic functions during development of head.
| Apoptotic engagement of caspases—summary | ||
|---|---|---|
| Brain | Regulation of neural cells population by elimination of excessive neurons: casp-3, -9 and Apaf-1, Bax | Kuida et al. (1996), Cecconi et al. (1998), Hakem et al. (1998), Jung et al. (2008) |
| Protection of neurons: casp-2 | Bergeron et al. (1998) | |
| Neural tube formation: casp-8 | Varfolomeev et al. (1998), Sakamaki et al. (2002) | |
| Development of motoneurons, sympathetic and sensory neurons: Bcl-2 | Michaelidis et al. (1996) | |
| Eye | Apoptosis in the inner nuclear layer of retina: casp-3 | Zeiss et al. (2004) |
| Lens transparency: casp-3 | Ishizaki et al. (1998), Zandy et al. (2005) | |
| Inner ear | Abnormal anatomy of inner ear: casp-3 | Makishima et al. (2011) |
| Decreased apoptosis in the inner ear epithelium: casp-9, Apaf-1 | Cecconi et al. (2004) | |
| Skull | Activation in apoptotic cells of mandible during prenatal development: casp-3, -7 and -8 | Svandova et al. (2018) |
| Palatal shelves | Fusion of palatal shelves ex vivo: General caspase activity | Cuervo et al. (2002) |
| Lack of adherence in palatal shelves: Apaf-1 | Honarpour et al. (2000) | |
| Absence of MES disintegration: Apaf-1 | Cecconi et al. (1998) | |
| Teeth | Apoptosis of cells in primary enamel knot: casp-3, -9 and, Apaf-1 | Setkova et al. (2007) |
| Skeletal muscles | Destruction of myonuclei and myofibers in aging tongue muscle: casp-3 | Kletzien et al. (2018) |
| Skin | Skin homeostasis: casp-8 | Kovalenko et al. (2009) |
| Melanin synthesis: Bcl-2 | Veis et al. (1993) | |
| Salivary glands | Temporarily restricted regulation of duct size in salivary glands ex vivo: General caspase activity | Teshima et al. (2016b) |
Apoptosis-related molecules are shown in bold font.