TABLE 3.
Overview of caspase non-lethal functions during development of head.
| Non-lethal engagement of caspases—summary | ||
|---|---|---|
| Brain | Regulation of neural differentiation: casp-2,-3,-9 | Fernando et al. (2005), Aranha et al. (2009), Pistritto et al. (2012) |
| Reorganisation of cells during neural tube closure ex vivo: General caspase activity | Shinotsuka et al. (2018) | |
| Axon branching: casp-3, -9 | Campbell and Okamoto (2013), Katow et al. (2017) | |
| Axon pruning: casp-3,-6, -9 | Cusack et al. (2013) | |
| Axon guidance: casp-9, Apaf-1 | Ohsawa et al. (2010) | |
| Eye | Vascularisation of retina: casp-8 | Tisch et al. (2019) |
| Proper thickness of retina: Apaf-1 | Honarpour et al. (2000) | |
| Proper development of retina and lens: Bcl-2 superfamily | Mosinger Ogilvie et al. (1998), Sanders and Parker (2003) | |
| Inner ear | Development of spinal ganglion and hair cells: casp-3 | Morishita et al. (2001), Takahashi et al. (2001) |
| Skull | Ossification of the skull: casp-3 | Miura et al. (2004) |
| Bone volume of mandible: casp-7, Fas/FasL | Svandova et al. (2014), Svandova et al. (2019) | |
| Teeth | Mineralization of enamel: casp-7 | Matalova et al. (2012), Matalova et al. (2013) |
| Skeletal muscles | Differentiation of skeletal muscles: casp-3, -8 | Fernando et al., 2002 |
| Skin | Terminal differentiation of keratinocytes: casp-14 | Lippens et al. (2000) |
| Regulation of mast cells population: casp-7 | Vesela et al., 2015 | |
| Blood vessels | Proliferation, sprouting and migration of endothelial cells: casp-8 | Varfolomeev et al. (1998) |
Apoptosis-related molecules are shown in bold font.