Table 1.
Basic characteristics of enrolled healthy volunteers and patients with ESCC
| Variable | HC (n = 34) | ESCC pre (n = 34) | ESCC post (n = 34) | P value (HC vs. ESCC pre) | P value (ESCC pre vs. ESCC post) |
|---|---|---|---|---|---|
| Age(year) | 0.745 | — | |||
| Median | 67 | 67 | 67 | ||
| Range | 56–78 | 54–77 | 54–77 | ||
| Gender[No. (%)] | 0.291 | — | |||
| Male | 21 (64.7) | 26 (76.5) | 26 (76.5) | ||
| Female | 13 (35.3) | 8 (23.5) | 8 (23.5) | ||
| ALT(U/l) | 0.367 | 0.104 | |||
| Medium | 19.5 | 18 | 24 | ||
| Range | 9–43 | 10–51 | 12–132 | ||
| AST(U/l) | 0.059 | 0.216 | |||
| Medium | 24 | 21 | 22.5 | ||
| Range | 15–36 | 12–43 | 9–62 | ||
| Creatinine (μmol/l) | 0.267 | 0.031 | |||
| Medium | 78.65 | 70 | 67.5 | ||
| Range | 50.9–108.3 | 48–129 | 39–102 | ||
| Hepatic or renal function(No.) | |||||
| Normal | 34 | 34 | 33 | — | 0.314 |
| Abnormal | 0 | 0 | 1 | ||
| TNM stage [No. (%)] | |||||
| Ⅰ | 9 (26.5) | ||||
| Ⅱ | 18 (52.9) | ||||
| III | 6 (17.6) | ||||
| VI | 1 (2.9) | ||||
| Tumor grade [No. (%)] | |||||
| 1 | 7 (18.4) | ||||
| 2 | 18 (47.4) | ||||
| 3 | 3 (7.9) | ||||
| Unclassified | 6 (15.8) | ||||
| Lymph node metastasis [No. (%)] | |||||
| Positive | 12 (35.3) | ||||
| Negative | 22 (64.7) |
Note: Hepatic abnormality as defined by ALT > 2.5× normal value or AST > 2.5× normal value, while renal abnormality as defined by creatinine > 2.5× normal value. HC, healthy control; ESCC, esophageal squamous cell carcinoma; ESCC pre, ESCC pre-esophagectomy; ESCC post, ESCC post-esophagectomy; ALT, alanine aminotransferase; AST, aspartate aminotransferase; —, not applicable.