Table 3.
Associations between trial characteristics and registration status in logistic regression
| Characteristicsa | Registered n = 432 |
Non- registered n = 41 |
Univariable | Multivariableb | ||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | p-value | OR | 95% CI | p-value | |||
| Single center (compared to multicenter) | 219 (85.9%) | 36 (14.1%) | 0.14 | 0.05-0.34 | < 0.001 | 0.20 | 0.064-0.60 | 0.003 |
| Investigator (compared to industry) sponsorship | 306 (89.5%) | 36 (10.5%) | 0.34 | 0.11-0.81 | 0.026 | 1.66 | 0.64-7.59 | 0.42 |
| Risk category low | 201 (84.5%) | 37 (15.5%) | Reference | Reference | ||||
| Risk category intermediate | 81 (97.6%) | 2 (2.4%) | 7.45 | 2.21-46.52 | 0.006 | 5.26 | 1.74-37.54 | 0.026 |
| Risk category high | 150 (98.7%) | 2 (1.3%) | 13.81 | 4.14-85.74 | < 0.001 | 9.00 | 2.56-71.32 | 0.008 |
| Use of CTU service (compared to. no service) | 103 (99.0%) | 1 (1.0%) | 12.52 | 2.67-223.52 | 0.013 | 15.63 | 3.24-281.23 | 0.007 |
Abbreviations: OR odds ratio, CI confidence, CTU Clinical Trials Unit
aReference values: sample size < 100, multi-center trials, investigator-initiated trials and drug trials
bThe variables Single center/ Multicenter, Sponsorship, Risk category, and Use of CTU services were included in the multivariable logistic regression