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Hotspot residues.
| Residue number | ΔΔGbinding (kcal/mol) | |
|---|---|---|
| Delta | Y449 | 1.30 |
| L455 | 1.07 | |
| F456 | 1.77 | |
| F486 | 1.79 | |
| N487 | 1.07 | |
| Y489 | 1.66 | |
| G498 | 1.63 | |
| N501 | 1.83 | |
| Y505 | 3.08 | |
| Omicron | Y453 | 1.63 |
| F456 | 1.61 | |
| F486 | 1.24 | |
| N487 | 1.16 | |
| Y489 | 2.09 | |
| R493 | 1.38 | |
| R498 | 1.49 | |
| Y501 | 1.69 |
Residues with ΔΔG > 1 kcal/mol as calculated by computational alanine scanning.
