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. 2023 Jan 11;15(3):3781–3790. doi: 10.1021/acsami.2c19305

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© 2023 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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The intracellular distribution and in vitro cytotoxicity of the nanoparticles. (A) The flow cytometry analysis of PI@MIL-100 uptake by liver cancer cell lines at different time points. (B) Immunofluorescence images of normal hepatic epithelial cells and liver cancer cells treated with PI@MIL-100 for 4 h (scale bar is 100 μm). (C) Detection of ROS levels of PLC/PRF/5 cells treated with Oxa@MIL-PDA-PEGTK with or without 808 nm laser irradiation (scale bar is 100 μm). (D) PLC/PRF/5 cells were treated with Oxa@MIL-PDA-PEGTK for 4 h and then irradiated with 808 nm laser. Microscopy images were taken after stained with LIVE/DEAD kit (scale bar is 100 μm). (E) Cell viability of L02 cells treated with Oxa@MIL-PDA-PEGTK at different concentrations. (F) Cell viability of PLC/PRF/5 cells treated with different NPs.