TABLE 1.

Test compounds concentrations and n values

Drug	Concentration	nHS	nLS
Antagonists
MLA	100 μM	8	4
DHβE	10 μM	8	7
α7 silent agonists
NS6740	30 μM	8	8
n-MP	300 μM	7	8
triEMA	100 μM	7	8
α9 agonists
pCN diEPP	100 μM	8	7
pCONH2-diEPP	100 μM	7	7
diMPiPa	100 μM	8	7
α4β2 modulators
NS9283b	30 μM	8	8
dFBr	30 μM	8	7
Non-selective agonists
Carbachol	100 μM	6	8
Epibatidine	3 μM	8	6
Anabaseine	100 μM	7	8
Nicotine	10 μM	7	8
Cotinine	100 μM	6	8
Nor-nicotine	10 μM	5	6
Anatabine	100 μM	4	8
HS selective agonists
sazetidine-A	30 μM	7	7
TC-2559	30 μM	6	8
α4β2 partial agonists
TC-2403	10 μM	8	8
cytisine	100 μM	6	6
varenicline	10 μM	7	7
arecoline	100 μM	8	7
α7-selective agonists
GTS-21	100 μM	7	7
PNU-282987	10 μM	8	8
TC-1698	10 μM	8	8
AR-R17779	10 μM	7	5
choline	1 mM	7	8

^a1,1-dimethylpiperidinium.

^b3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile 3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile.