Table 3.
Frequency of cognitive and behavioral features of the 17 CM-AD patients emerged at baseline (T0) (absolute frequency) and longitudinal assessment (cumulative frequency)
| Visit/months | T0 | T12 | T24 | T36 | T48 | T60 | T72> | |
| Years from onset | 3 y | 4 y | 5 y | 6 y | 7 y | 8 y | 9 y | |
| Stage (CDR) | 0.5–1 | 0.5–1 | 1 | 1-2 | 2 | 2 | 2-3 | |
| n° patients | 17 | 17 | 11 | 8 | 5 | 3 | 3 | |
| Absolute frequency | Cumulative frequency | Cumulative frequency | Cumulative frequency | Cumulative frequency | Cumulative frequency | Cumulative frequency | ||
| N | % | % | % | % | % | % | % | |
| Recent memory deficits | 16 | 94.1 | 100 | |||||
| Temporal disorientation | 15 | 88.2 | ||||||
| Confabulation | 15 | 88.2 | ||||||
| Executive functions deficits | 15 | 88.2 | 88.2 | 88.2 | 94.1 | |||
| Attention deficits | 14 | 82.3 | ||||||
| Reduced Insight | 13 | 76.5 | 76.5 | 82.3 | 88.2 | |||
| Past memory deficits | 11 | 64.7 | ||||||
| Psychomotor slowness | 10 | 58.8 | ||||||
| Topographical disorientation | 7 | 41.2 | 76.5 | 76.5 | 82.3 | 82.3 | 88.2 | |
| Delusion (not-misidentification) | 7 | 41.2 | 41.2 | 41.2 | 70.6 | |||
| Apathy | 7 | 41.2 | 52.9 | 64.7 | 82.3 | |||
| Language deficits | 6 | 35.3 | 52.9 | 58.8 | 70.6 | 76.5 | ||
| Aggression | 6 | 35.3 | 47.1 | 47.1 | 58.8 | 58.8 | 64.7 | |
| Anxiety | 6 | 35.3 | 52.9 | 58.8 | 64.7 | 70.6 | ||
| Logorrhea | 5 | 29.4 | ||||||
| Misidentification | 4 | 23.5 | 23.5 | 41.2 | 47.1 | 47.1 | 52.9 | |
| Irritability | 4 | 23.5 | 41.2 | 58.8 | 70.6 | 76.5 | ||
| Hallucination | 3 | 17.6 | 29.4 | 47.1 | 64.7 | |||
| Fluctuations | 3 | 17.6 | 23.5 | 35.3 | 47.1 | 52.9 | ||
| Visit/months | T0 | T12 | T24 | T36 | T48 | T60 | T72> | |
| Years from onset | 3 y | 4 y | 5 y | 6 y | 7 y | 8 y | 9 y | |
| Stage (CDR) | 0.5–1 | 0.5–1 | 1 | 1-2 | 2 | 2 | 2-3 | |
| n° patients | 17 | 17 | 11 | 8 | 5 | 3 | 3 | |
| Absolute frequency | Cumulative frequency | Cumulative frequency | Cumulative frequency | Cumulative frequency | Cumulative frequency | Cumulative frequency | ||
| Social disinhibition | 3 | 17.6 | ||||||
| Euphory/Fatuity | 3 | 17.6 | ||||||
| Insomnia | 3 | 17.6 | 52.9 | 64.7 | 70.6 | |||
| Depression | 3 | 17.6 | 35.3 | 58.8 | 70.6 | |||
| Praxis deficits | 2 | 11.8 | 23.5 | 29.4 | 47.1 | 47.1 | 47.1 | 52.9 |
| Hypersomnia | 2 | 11.8 | ||||||
| Rem Behavior Disorders (RBD) | 2 | 11.8 | ||||||
| Lability | 2 | 11.8 | ||||||
| Abulia | 1 | 5.9 | ||||||
| Obsession- Compulsion | 1 | 5.9 | ||||||
| Hyperactivity/psychomotor agitat. | 1 | 5.9 | 35.3 | 52.9 | 76.5 | |||
| Personality changes | 0 | 0 | ||||||
| Wandering | 0 | 0 | ||||||
| Purposeless activity | 0 | 0 | ||||||
| Impulse control disorders | 0 | 0 | ||||||
| Hyperfagia | 0 | 0 | 17.6 | 29.4 | 47.1 | 64.7 | 70.6 | 76.5 |
| Confusional arousal | 0 | 0 | ||||||
We marked in bold the main features of the CM-phenotype which emerged in more than 50%of the patients at the first visit and follow-ups. In addition, we marked in bold the frequency of a feature (both absolute or cumulative) when it reached the highest value considering the whole period of observation. Finally, we did not report the cumulative frequency of a feature at follow-up either when it never reached 50%or when it had already reached its highest value at the first visit. We displayed cumulative instead of absolute frequencies at the geriatric follow-ups since longitudinal data resulted be quite incomplete, especially later than 24 months from baseline. On the other hand, cumulative frequencies well capture how much a feature was common in the phenotype.