Table 5.
Comparison of cognitive and behavioral features reported at geriatric follow-up visits at 12 and 24 months between patients with the CM and CA phenotype (Statistically significant differences are in bold)
| T12 | T24 | |||||||||
| CM | CA | CM | CA | |||||||
| N = 17 | % | N = 27 | % | p | N = 11 | % | N = 19 | % | p | |
| Cognitive features | ||||||||||
| Fluctuations | 3 | 17.6% | 1 | 3.7% | 0.282* | 2 | 18.2% | 4 | 21.1% | 1.000* |
| Sundowning | 1 | 5.9% | 3 | 11.1% | 1.000* | 0 | 0 | 1 | 5.3% | 1.000* |
| Psychomotor slowness | 1 | 5.9% | 1 | 3.7% | 1.000* | 1 | 9.1% | 0 | 0 | 0.367* |
| Confusional episodes | 0 | 0 | 2 | 7.4% | 0.515* | 1 | 9.1% | 0 | 0 | 0.367* |
| Recent memory deficits | 15 | 88.2% | 23 | 85.2% | 1.000* | 5 | 45.4% | 12 | 63.2% | 0.454* |
| Retrograde memory deficits | 2 | 11.8% | 8 | 29.6% | 0.271* | 0 | 0 | 1 | 5.3% | 1.000* |
| Confabulation | 4 | 23.5% | 1 | 3.7% | 0.065* | 0 | 0 | 0 | 0 | nv |
| Temporal disorientation | 6 | 35.3% | 7 | 25.9% | 0.507 | 2 | 18.2% | 2 | 10.5% | 0.611* |
| Topographical disorientation | 11 | 64.7% | 12 | 44.4% | 0.190 | 3 | 27.3% | 6 | 31.6% | 1.000* |
| Attention deficits | 5 | 29.4% | 14 | 51.8% | 0.143 | 1 | 9.1% | 1 | 5.3% | 1.000* |
| Executive function deficits | 7 | 41.2% | 9 | 33.3% | 0.598 | 3 | 27.3% | 2 | 10.5% | 0.327* |
| Reduction of insight | 10 | 58.8% | 7 | 25.9% | 0.029 | 3 | 27.3% | 1 | 5.3% | 0.126* |
| Language deficits | 7 | 41.2% | 17 | 63% | 0.158 | 3 | 27.3% | 5 | 26.3% | 1.000* |
| Praxis deficits | 5 | 29.4% | 7 | 25.9% | 1.000* | 4 | 36.4% | 2 | 10.5% | 0.156* |
| Behavioral features | ||||||||||
| Misidentification | 4 | 23.5% | 2 | 7.4% | 0.186* | 3 | 27.3% | 2 | 10.5% | 0.327* |
| Delusion not-misidentification | 7 | 41.2% | 7 | 25.9% | 0.290 | 5 | 45.4% | 7 | 36.8% | 0.712* |
| Hallucination | 7 | 41.2% | 3 | 11.1% | 0.030* | 3 | 27.3% | 3 | 15.8% | 0.641* |
| Apathy | 8 | 47.1% | 9 | 33.3% | 0.363 | 4 | 36.4% | 2 | 10.5% | 0.156* |
| Abulia | 1 | 5.9% | 5 | 18.5% | 0.380* | 2 | 18.2% | 1 | 5.3% | 0.537* |
| Irritability | 8 | 47.1% | 14 | 51.8% | 0.757 | 5 | 45.4% | 9 | 47.4% | 0.919 |
| Aggression | 6 | 35.3% | 8 | 29.6% | 0.694 | 5 | 45.4% | 6 | 31.6% | 0.696* |
| Social disinhibition | 4 | 23.5% | 0 | 0 | 0.018* | 2 | 18.2% | 0 | 0 | 0.126* |
| Impulse control disorder | 0 | 0 | 1 | 3.7% | 1.000* | 0 | 0 | 0 | 0 | nv |
| Obsession-compulsion | 1 | 5.9% | 1 | 3.7% | 1.000* | 0 | 0 | 0 | 0 | nv |
| Hyperactivity (psychomotor agit.) | 5 | 29.4% | 7 | 25.9% | 1.000* | 5 | 45.4% | 5 | 26.3% | 0.425* |
| Wandering | 3 | 17.6% | 3 | 11.1% | 0.662* | 0 | 0 | 2 | 10.5% | 0.520* |
| Purposeless activity | 4 | 23.5% | 8 | 29.6% | 0.739* | 3 | 27.3% | 9 | 47.4% | 0.442* |
| Hyperphagia | 3 | 17.6% | 3 | 11.1% | 0.662* | 2 | 18.2% | 0 | 0 | 0.126* |
| Euphory/fatuity | 1 | 5.9% | 1 | 3.7% | 1.000* | 0 | 0 | 0 | 0 | nv |
| Insomnia | 7 | 41.2% | 10 | 37% | 0.784 | 4 | 36.4% | 6 | 31.6% | 1.000* |
| Hypersomnia | 2 | 11.8% | 5 | 18.5% | 0.689* | 4 | 36.4% | 2 | 10.5% | 0.156* |
| Rem behavior disorder (RBD) | 3 | 17.6% | 1 | 3.7% | 0.282* | 1 | 9.1% | 2 | 10.5% | 1.000* |
| Confusional arousal | 2 | 11.8% | 0 | 0 | 0.144* | 0 | 0 | 0 | 0 | nv |
| Lability | 2 | 11.8% | 4 | 14.8% | 1.000* | 2 | 18.2% | 1 | 5.3% | 0.537* |
| Anxiety | 6 | 35.3% | 13 | 48.1% | 0.402 | 4 | 36.4% | 4 | 21.1% | 0.417* |
| Depression | 9 | 52.9% | 17 | 63% | 0.510 | 6 | 54.5% | 6 | 31.6% | 0.266* |
nv, no variability in the data. *Fisher’s exact test.