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The low bioavailability of 7,8-DHF could be overcome by modifying the structure of 7,8-DHF through prodrug strategy, glycation, derivative compounds, and molecular docking methods and preparing 7,8-DHF nano-preparations. (DHF-Z-S: 7,8-DHF loaded zein-sophorolipid nanoparticles, zein/LF-DHF: 7,8-DHF loaded zein/lactoferrin composite nanoparticles).
