TABLE 1.
Influence of rmIL-12 treatment on survival after sublethal CLPa
| Time of rmIL-12 treatment | No. of mice surviving/no. tested after treatment with rmIL-12 at (ng per mouse):
|
||||
|---|---|---|---|---|---|
| 0 | 10 | 30 | 100 | 1,000 (twice) | |
| Immediately after CLP | 4/5 | 3/5 | 5/5 | 5/5 | nt |
| Day −1 | 5/5 | 5/5 | 2/4 | 1/5 | nt |
| Days −2 and −1 | 11/12 | nt | nt | nt | 1/12 |
a
Groups of mice were treated with the indicated amounts of rmIL-12 i.p. immediately after sublethal CLP (day 0) or on day −1 or both days −2 and −1. The data are given as cumulative survival of the animals over a period of 7 days after CLP. nt: not tested.