Fig. (1).

Human variants in K_Na channels subunits topography. (A) Schematic diagram of Slack channels subunits topography. (B) Schematic diagram of Slick channels subunits topography. Red sites represent variants which are found in patients with EIMFS. Black sites represent variants which are found in patients with ANDFLE or NFLE. Green sites represent mutation sites that are found in patients with other severe epilepsy, such as OS, EOEE, West syndrome, leuko-encephalopathy et al. Orange sites represent mutation sites that are found in three phenotypes. *sites represent mutation are showed in EIMFS and other severe epilepsy patients. # sites represent variants are showed in EIMFS and ADNFLE patients. ¨represent variants are showed in ADNFLE and other severe epilepsy patients. ☆ sites represent variants with loss of function.