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. 2022 Dec 7;51(2):e12. doi: 10.1093/nar/gkac1136

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Age alters NAD-capped RNAs. (A) Pathway analysis reveals the biological processes of NAD-capped RNAs are mainly involved in DNA replication, transcription, cell cycle, metabolism, immune system, response to stimulus, and ribosome biogenesis. Grey dashed line in the bar plot indicates the 0.05 q-value cutoff. (B) Violin plot showing the global dynamics of NAD-RNAs during aging (***P < 0.001 by Wilcox rank-sum test). Both the number of RNAs that contain NAD-capped form and the global extent of capping become decreased in aged (18-month) compared to young (2-month) mouse livers. (C) Scatter plot of NAD-capped RNAs in young and aged mouse livers. Common NAD-RNAs were shown in grey. Specific NAD-RNAs were found in both young (2-month, blue) and aged (18-month, yellow) mouse livers. (D) Network of functional pathways for genes that contains NAD-cap from young and aged mouse livers, respectively. Nodes represent pathways and edges represent shared genes between pathways. Nodes colored in blue are young-specific pathways (2-month) and those in khaki are aged-specific pathways (18-month), while those in both colors are shared by both young and aged animals.