Table 4.

Clinical trials based on MSCs transplantation in IBD patients

Disease	Phase	Source	Administration route (dose)	Participant Number	Study location	Status	NCT number
CD	1	Allogeneic UC	Intravenous	15	Antigua and Barbuda	Recruiting	NCT05003947
UC	1/2	Allogeneic WJ	Intravenous	20	Jordan	Unknown	NCT03299413
CD	2	Allogeneic BM	Intravenous	10	USA	Completed	NCT00294112
CD	1	Allogeneic BM	NA	10	Iran	Unknown	NCT01874015
CD	1/2	Autologous AT	Intracolonic	15	Spain	Completed	NCT01157650
UC	1/2	Allogeneic AT	Intracolonic	8	Spain	Unknown	NCT01914887
CD	1/2	Allogeneic UC	Intravenous	82	China	Completed	NCT02445547
CD	1/2	Allogeneic BM	Intravenous	13	Belgium	Terminated	NCT01540292
CD	1	Allogeneic BM-EVs	Intravenous	10	USA	Not yet recruiting	NCT05130983
UC	1/2	Allogeneic UC	Intravenous	50	China	Unknown	NCT01221428
CD	1/2	Allogeneic BM	Intracolonic	21	Netherlands	Completed	NCT01144962
CD	1/2	Allogeneic BM	Intracolonic	40	USA	Recruiting	NCT04519684
CD	1/2	Allogeneic BM	Intracolonic	40	USA	Recruiting	NCT04519697
UC	1/2	Allogeneic BM	Intracolonic	20	USA	Not yet recruiting	NCT05075811
CD	1	Allogeneic UC	Intracolonic	7	Malaysia	Not yet recruiting	NCT05039411
CD	1	Allogeneic BM	Intracolonic	10	USA	Recruiting	NCT04791878
CD	3	Allogeneic AT	Intracolonic	278	International	Completed	NCT01541579
CD	1/2	Allogeneic BM	Intracolonic	24	USA	Recruiting	NCT04548583
UC	1/2	Allogeneic AT	Intracolonic	50	China	Recruiting	NCT03609905
CD	3	Allogeneic BM	Intravenous	330	International	Completed	NCT00482092
UC	1/2	Allogeneic UC	Intravenous	30	China	Unknown	NCT02442037
CD	3	Allogeneic BM	Intravenous	98	International	Completed	NCT00543374
UC	1/2	Allogeneic BM	Intracolonic	24	USA	Recruiting	NCT04543994
CD	1	Allogeneic UC	Intracolonic	24	China	Enrolling by invitation	NCT04939337
UC	1	Autologous AT	Intraarterial	20	USA	Recruiting	NCT04312113

MSCs mesenchymal stem/stromal cells, EVs extracellular vesicles, BM bone marrow, UC umbilical cord, AT adipose tissue, WJ Wharton's jelly, CD Crohn's disease, UC ulcerative colitis, NA not applicable