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. 2023 Jan 27;2023(1):CD012664. doi: 10.1002/14651858.CD012664.pub2

Rourke 1998.

Study characteristics
Methods Randomised, controlled, parallel‐group trial (2 groups)
Duration of study: not specified
Duration of follow‐up: 1 year
Participants Setting characteristic: athletes
Included: healthy women, athletes from collegiate teams
Excluded: screened athletes denied the use of steroids, anticonvulsants, or tobacco
Age: 18–22 years
  • Calcium: 19.9 (SD 0.2) years

  • Placebo: 19.2 (SD 0.3) years


Sample:
Total included 30
  • Calcium group: 17 (baseline), 17 (6 months), and 17 (12 months)

  • Placebo group: 13 (baseline), 13 (6 months), and 13 (12 months)


Country: USA
Interventions Calcium versus placebo
Intervention group:
  • elemental calcium supplementation 1000 mg


Control group:
  • placebo


Administration: daily
Duration of treatment: 1 year
Outcomes BMD: lumbar spine (L1–L4), total hip, femoral neck, trochanter, wards triangle, and radius.
Anthropometric measures: height, weight, BMI, % body fat, VO2max.
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not specified.
Allocation concealment (selection bias) Unclear risk Not specified.
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Not specified.
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk Not specified.
Incomplete outcome data (attrition bias)
All outcomes High risk The reasons for the loss of 33% of the participants were not explained. The study began with 45 participants and finished with 30 participants. The study authors presented only the analysis per protocol (calcium group 17 participants and placebo group 13 participants).
Selective reporting (reporting bias) Unclear risk Not specified.
Other bias High risk Problems with adherence to treatment. "Compliance data suggest that the CS [calcium] group failed to consume the prescribed 1000 mg daily intake of calcium. Furthermore, subjects in the placebo group reported a higher intake of calcium when compared with the CS group."