. Author manuscript; available in PMC: 2023 Oct 1.

Published in final edited form as: Depress Anxiety. 2022 Jul 14;39(10-11):706–717. doi: 10.1002/da.23277

Table 3. Statistical Results for Models Examining Early-life Unpredictability Associations with Psychiatric Symptoms.

Table 3 depicts the original statistical model to examine contribution of early life unpredictability to psychiatric symptoms at Visit 1 (Table 3A) followed by models comparing contribution of unpredictability and childhood trauma at Visit 1 (Table 3B) and main effects of unpredictability across all 3 visits (Table 3C).

A. Early-life Unpredictability Alone
	QUIC			Overall Regression
	β	t	p	Adj. R²	F	p
Anxiety (GAD-7)	0.25	3.10	0.002	0.056	9.63	0.002
Depression (PHQ-9)	0.247	3.07	0.003	0.055	9.43	0.003
Anhedonia (MASQ-AD)	0.258	3.21	0.002	0.06	10.3	0.002
PTSD (PCL-5)	0.214	2.64	0.009	0.039	6.94	0.009
	%ΔSI	z	p
Suicidal Ideation (PHQ-9)	4.4% (1.7–7.0)	3.35	0.0008
Suicidal Ideation (MASQ)		1.68	0.094

B. Early-life Unpredictability Compared to Childhood Trauma
	QUIC			CTQ			Overall Regression
	β	t	p	β	t	p	Adj. R²	F	p	ΔR²
Anxiety (GAD-7)	0.176	2.18	0.031	0.185	2.30	0.023	0.052	5.02	0.008	0.031
Depression (PHQ-9)	0.159	1.976	0.05	0.206	2.55	0.01	0.055	5.21	0.007	0.025
Anhedonia (MASQ-AD)	0.192	2.39	0.018	0.176	2.18	0.03	0.055	5.24	0.006	0.037
PTSD (PCL-5)	0.128	1.57	0.118	0 .192	2.37	0.019	0.04	4.05	0.019	NS
	%ΔSI	z	p	%ΔSI	z	p
Suicidal ideation (PHQ-9)	2.15 (2.74-.58)	1.74	0.082	4.0 (1.32–6.68)	3.15	0.002				NS

C. Early-life Unpredictability Associations with Symptoms When Collapsed Across 3 Visits
	QUIC
	beta^*	t	p
Anxiety (GAD-7)	0.16	3.21	0.002
Depression symptoms (PHQ-9)	0.18	3.13	0.002
Anhedonia (MASQ-AD)	0.53	3.8	0.0002
PTSD symptoms (PCL-5)	0.51	2.82	0.005
Suicidal ideation (PHQ-9 item 9)	0.04	2.17	0.03

%ΔSI=percent change in suicidal ideation with for every unit increase in QUIC total

ΔR²= We conducted a series of hierarchical linear regressions in R Studio to inspect the change in R-square ( $Δ$ R²) with the addition of the QUIC to the CTQ in explaining variance in our primary outcome variables. See results section for details. NS=Not significant.

the lmer function does not provide a standardized beta value